A new study published in the journal Science claims there’s a genetic mechanism that links emotional experiences to behavioral changes.

According to researchers, this genetic mechanism regulates behavioral adaptations to emotional experiences by forming R-loops, unique RNA:DNA structures that activate target genes. The study focused on NPAS4, a gene implicated in stress and drug addiction, showing how blocking R-loops prevents maladaptive behaviors like stress-induced anhedonia (a condition that involves a reduced ability to experience pleasure or interest in activities that were once enjoyable).

This mechanism demonstrates how emotional experiences influence brain circuits by altering gene expression through enhancer RNA. The findings could pave the way for RNA-based therapies to treat psychiatric disorders linked to stress and substance use. Here’s more: https://www.science.org/doi/10.1126/science.adp1562‍

A new study published in the Journal of Behavioral Addictions revealed brain activity patterns that may predict gaming addiction in teens. 

The study of adolescents found reduced activity in brain regions linked to decision-making and reward processing in those developing gaming addiction symptoms over four years. 

This blunted response to non-gaming rewards suggests that some teens are more susceptible to problematic gaming behaviors. Researchers believe the findings could help clinicians identify at-risk individuals early. Check it out: https://akjournals.com/view/journals/2006/aop/article-10.1556-2006.2024.00068/article-10.1556-2006.2024.00068.xml

A new study was published in the journal Nature Communications that shows how slow-wave sleep strengthens synaptic connections in the neocortex, making it more receptive to long-term memory formation.

Researchers found that during deep sleep, synapses in the neocortex reach peak efficiency at precise moments within slow-wave oscillations. This process allows the brain to effectively transfer information from short-term storage in the hippocampus to long-term memory. The findings could refine techniques like electrical stimulation to enhance memory in conditions such as mild cognitive impairment, offering a targeted approach to boosting memory retention. Here’s more: https://www.nature.com/articles/s41467-024-53901-2

Did you know that Colorado’s first psilocybin clinics are expected to open this summer?

In 2022, a ballot measure passed to decriminalize the personal use of certain psychedelic substances, including psilocybin. There’s also a state program that will allow patients to consume psilocybin at what regulators call “healing centers.”

As reported by journalist Marissa Ventrelli, patients seeking to consume psilocybin must undergo a four-step assessment phase, where individuals go through a screening process to determine any risk factors and match them with a facilitator. Potential patients are asked about why they're seeking psychedelic therapy, their history of psychedelic use, and their medical and mental health history.

If any risk factors are determined through the screening, they are reviewed by professionals before the patient is moved into the preparation phase.

During preparation, patients meet with their facilitators to discuss what they hope to get out of their session and develop a safety plan to handle any negative emotions or memories that may surface following the treatment. After a plan is established, patients visit a healing center where they receive their treatment. 

Here’s more: https://www.coloradopolitics.com/health-care/colorado-legalizes-psilocybin-healing-centers/article_c3f076f6-b357-11ef-a9b1-d7ce43aca8ed.html