Enveric Biosciences announced the completion of preclinical animal pharmacokinetic (PK) studies further supporting the oral bioavailability and targeted non-hallucinogenic profile of EB-003. This is the company’s lead molecule designed to promote neuroplasticity, without inducing hallucinations, in patients suffering from difficult-to-address mental health disorders.

The PK studies demonstrated oral bioavailability in rat and dog studies that were dose-proportional, as was also shown previously in a mouse model. Brain penetration was demonstrated and no evidence of hallucination-like behavior was found. 

The data gained in these animal studies brings Enveric one step closer to finalizing its data package for the EB-003 Investigational New Drug (IND) application, which the company expects to submit to the U.S. Food and Drug Administration in the second half of 2025.  Here’s more: https://www.enveric.com/news/enveric-biosciences-preclinical-pharmacokinetic-studies-of-eb-003-support-oral-bioavailability-demonstrate-brain-penetration-and-show-no-evidence-of-hallucination-like-behavior/

Researchers from University College London published a new study that suggests AI can predict the results of proposed neuroscience studies more accurately than human experts.

Their findings demonstrated that large language models trained on vast datasets of text can distill patterns from scientific literature, enabling them to forecast scientific outcomes with superhuman accuracy.  The researchers noted that this highlights how AI can be used to accelerate research, going far beyond just knowledge retrieval.  Check it out: https://www.nature.com/articles/s41562-024-02046-9

A new study was published in JAMA Neurology that indicated long-term exposure to smoke concentrations is associated with a higher risk of dementia diagnosis over time. 

According to researchers, for every one microgram increase in wildfire pollution per cubic meter of air over the course of a three-year period, the odds of dementia diagnosis rise by about 18 percent.

The study focused on a form of air pollution known as particulate matter — tiny, inhalable particles, with diameters of 2.5 micrometers or smaller. This kind of air pollution can originate from a variety of sources, including automobiles, industrial sources and fires.

Previous studies already suggested that particulate matter can increase the risk of dementia, among other health problems. The new research, however, focuses specifically on particles produced by wildfire smoke, which can have different chemical and physical properties than particles produced by other sources. Here’s more: https://jamanetwork.com/journals/jamaneurology/fullarticle/2827124?guestAccessKey=fa5fca5a-bcdf-4801-a2dc-81b6e87b95dd&utm_source=for_the_media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=112524

Did you know that brain structures linked to musical memory remain mostly undamaged by Alzheimer’s? 

According to researchers, musical neural networks differ from traditional temporal memory-related neuronal pathways. Music memory retrieval includes network areas inside and outside of the temporal, frontal, and parietal lobes.

Scientists now believe that musical activity may actually have a protective role in age-related cognitive decline, with some recommending that folks start some kind of musical activity in their lives - regardless of age. This could be anything from learning to play an instrument to joining a choir to dancing at a club. Check it out: https://www.psychologytoday.com/intl/blog/how-my-brain-works/202411/the-relationship-between-music-and-alzheimers-disease